Next generation MXene based materials for electrochemical sensor: A critical review

•MXene with unique layered morphology have potential to be used as sensors.•The structural performance influences the efficiency of MXene-based sensors.•Utilization of new MXene materials for sensing in biomarker is highly anticipated.•The efficiency of MXene in hazardous pollutants detection was evaluated.•The challenges and future prospective of MXenes for sensing applications. MXene, an innovative two-dimensional layered material, exhibits significant potential in the realm of electrochemical sensing owing to its outstanding electrical conductivity, high biocompatibility, rich active sites, metallic conductivity and adjustable surface chemical properties. By combining MXene with other nanomaterials, synergistic and complementary effects can be achieved, leading to enhanced selectivity and sensitivity for electrochemical sensing applications. This makes MXene a promising material for various sensing applications in electrochemistry. This review article highlights different etching methods for the fabrication of MXene. It demonstrates the morphological features, synergistic effects, and unique characteristics resulting from various etching methods. Furthermore, this review article critically cover the application of MXene and MXene bases nanocomposites as electrochemical sensors for biomarkers (glucose sensors, H2O2 sensors, neurotransmitter sensor and cancer marker sensor) and environmental contaminants detection (pesticide sensors, phenol sensors, nitrite sensors and heavy metal ion sensors). This review article offers a comprehensive compilation of recent integrated research on the topic. Additionally, the current obstacles and future outlook are thoroughly examined. [Display omitted]