Catalyst-free synthesis of imidazo[5,1-b]quinazolines and their antimicrobial activity

•The efficient catalyst-free synthesis of imidazo[5,1-b]quinazoline derivatives 4(a-t).•Compound 4c and 4e (MIC = 25 µg/mL) shows most potent activity against E. coli and S. pyogenes than the standard drugs ampicillin (MIC = 100 µg/mL) and chloramphenicol (MIC = 50 µg/mL) respectively.•Compond 4k (I...

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Veröffentlicht in:Journal of molecular structure 2023-08, Vol.1285, p.135467, Article 135467
Hauptverfasser: Patel, Paras J., Vala, Ruturajsinh M., Patel, Subham G., Upadhyay, Dipti B., Rajani, Dhanji P., Damiri, Fouad, Berrada, Mohammed, Patel, Hitendra M.
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Sprache:eng
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Zusammenfassung:•The efficient catalyst-free synthesis of imidazo[5,1-b]quinazoline derivatives 4(a-t).•Compound 4c and 4e (MIC = 25 µg/mL) shows most potent activity against E. coli and S. pyogenes than the standard drugs ampicillin (MIC = 100 µg/mL) and chloramphenicol (MIC = 50 µg/mL) respectively.•Compond 4k (IC50 = 0.28 µg/mL) showed antimalarial inhibition against P. falciparum similar to the standard quinine (IC50 = 0.27 µg/mL)•Single crystal structure evaluation of 4b shows a monoclinic system with P1 space group.•Molecular docking studies of 4e reveals good H-bonding interaction with ARG136 and ASN46.•In silico ADME prediction of compounds 4c, 4e and 4k show the most promising drug-likeness properties. In this study, imidazo[5,1-b]quinazoline derivatives 4(a–t) were synthesized via a three-component reaction of 5-aminoimidazole-4-carbonitrile, 1,3-cyclohexanedione derivatives and various aromatic aldehydes by employing glacial acetic acid as a reaction medium. This catalyst-free approach affords mild reaction conditions and has operational simplicity resulting in excellent yield in a shorter reaction time without any chromatographic separation method. All the synthesized compounds were screened for their antimicrobial activity against the pathogenic strains. The compounds 4c and 4e exhibit a more promising (MIC = 25 µg/mL) against S. pyogenes and E. coli bacterial strains than the standard drug ampicillin (MIC = 100 µg/mL) and chloramphenicol (MIC = 50 µg/mL) respectively. Compounds 4c, 4h, 4k and 4r showed pronounced antifungal activity (MIC = 250 µg/mL) against C. albicans compared to the standard drug griseofulvin (MIC = 500 µg/mL). Further, compound 4k was found to have good antimalarial inhibition (IC50 = 0.28 µg/mL) against P. falciparum, similar to the standard drug quinine (IC50 = 0.27 µg/mL). Binding interactions of 4e in the active site of E. coli DNA gyrase (PDB ID: 1KZN) showed good interaction with the target protein. Potent antimicrobial active compounds 4c, 4e and 4k showed drug-likeness with a good ADME profile. [Display omitted]
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2023.135467