Benzothiazole tethered triazole based potential antibacterial agent as a selective fluorometric probe for the detection of Al3+ ions and phenylalanine

•2-aminobenzothiazol based organosilane was synthesized that show selectivity and sensitivity only towards Al3+ ions and phenylalanine in UV–vis spectroscopy without any interference of other metal ions and amino acids, respectively.•The Benesi-Hildebrand (B-H) graph was plotted and its linearity confirms the 1:1 stoichiometry ratio of the ligand complex with Al3+ and Phenylalanine.•Further, fluorescence study demonstrated that ligand show turns-on and turn-off fluorescence in presence of Al3+ and Phenylalanine, respectively.•From stern-volmer plot, limit of detection (LOD), quencher rate coefficient (Ksv) was calculated for Al3+ and Phenylalanine was found to be 4.08 × 10−9 M, 7.79 × 106 M−1 and 18.45 × 10−6 M, 1.65 × 104 M−1, respectively.•Binding mode of a ligand with Al3+ and Phenylalanine was confirmed by synthesizing the complex and its characterization by 1H NMR spectroscopy.•The synthesized organosilane also possess antibacterial potential against gram-positive (Staphylococcus Aureus) and gram-negative (Escherichia Coli) bacteria at the minimum inhibitory concentration (MIC) of 0.039 mg/ml. The excess of Al3+ ions in the biological and environmental samples have negative impact and Phenylalanine deficiency can cause serious neurological abnormalities. Hence, there is a need of a simple and cost-effective chemosensor for the detection of Al3+ ions and Phenylalanine. Herein, we have designed a ligand that shows selectivity and sensitivity towards Al3+ ions and phenylalanine in absorption spectroscopy without any interference of other metal ions and amino acids respectively. The linearity of the B-H plot confirms the 1:1 stoichiometry ratio of the ligand with the ions and amino acid. Further, fluorescence study demonstrated that ligand shows turn-on and turn-off fluorescence in the presence of Al3+ ions and Phenylalanine with LOD values of 4.08 × 10−9 M and 18.45 × 10−6 M, respectively. The complexes of the synthesized receptor with Al3+ ions and Phenylalanine were synthesized and characterized by the 1H NMR to confirm the binding mode. Moreover, prepared molecules were subjected to in vitro microbiology assay against gram-positive and gram-negative bacteria and the results gave potential evidence of antibacterial activity against Staphylococcus Aureus and Escherichia Coli at the minimum inhibitory concentration (MIC) of 0.039 mg/ml.