Unveiling the potential: 1,3-benzodioxole-based ionic liquids as dynamic players against cancer

[Display omitted] •This review focused on natural analogs consisting of 1,3-benzodioxole motif.•The anticancer potential and mechanism of action of 1,3-benzodioxole motif discussed.•1,3-benzodioxole motif and ionic liquids based on 1,3-benzodioxole motif discussed.•Anticancer activity of 1,3-benzodioxole motif-based ionic liquids discussed. Cancer treatment remains challenging despite advancements in the field of medical science. Traditional therapies such as chemotherapy, surgery, and radiation have limitations in terms of high costs and adverse side effects. To address this issue, researchers are exploring innovative approaches that can provide effective cancer treatment with minimal side effects. In literature, various natural and synthetic compounds containing 1,3-benzodioxole scaffolds have shown effective anticancer activities. Due to the unique and tunable properties of ionic liquids, they have attracted researchers for the treatment of several cancers while minimizing harm to healthy tissues. The incorporation of the 1,3-benzodioxole scaffold with other organic compounds in the form of ionic liquid enhanced their therapeutic potential. This review aims to provide a comprehensive overview of the recent progress in the development of 1,3-benzodioxole-based ionic liquids. The review encompasses a detailed synthesis protocol, computational studies, and different spectroscopic approaches including UV–visible, fluorescence, and Circular Dichroism spectroscopy. Furthermore, it encompasses in-vitro studies, collectively representing a potentially transformative strategy to address the limitations associated with conventional drugs. Additionally, it underscores an emerging research domain with significant implications for the future of oncology.