Solubility parameter and solution thermodynamic properties of Form I Trimebutine maleate in six mono-solvents and three binary mixed solvents at different temperatures

•The solubility of Form I Trimebutine maleate in mono-solvents and binary mixed solvents was determined.•Solubility data was correlated by five models.•Thermodynamic parameters were estimated using the van’t Hoff equation. The solubility information of drugs in solution is of great significance in the fields of chemistry and pharmacy. Trimebutine maleate is a commonly used drug for treating gastrointestinal disorders, and its solid–liquid balance data are critical for a preliminary study of industrial application. This study investigated the solubility of medicinal crystal form (Form Ⅰ) of Trimebutine maleate at T = 283.15–328.15 K. The molar fraction solubility of Form Ⅰ in six mono-solvents and three binary mixtures were studied. The modified Apelblat equation, the general Buchowski-Ksiazaczak λh model and the new correlative model were used for correlation analysis of the solubility of Form Ⅰ in mono-solvents. The general cosolvency model and Jouyban-Acree-van't Hoff model were used for correlation analysis of the solubility of Form Ⅰ in binary mixed solvents. By comparing the models, the modified Apelblat equation and the general cosolvency model provided more accurate experimental data for predicting the solubility of Form Ⅰ in mono-solvents and binary mixed solvents, respectively. Finally, the apparent thermodynamic properties were calculated by the van't Hoff analysis.