Synthesis and aggregation behavior of novel biosurfactants choline cholate and choline deoxy cholate

[Display omitted] •Novel Choline cholate and Choline deoxycholate based biosurfactants were synthesized.•Biosurfactants display intriguing aggregation behavior captured through SAXS.•Biosurfactant display high foamability and foam stability.•Sphere to rod transition can be induced in the Biosurfactants.•Novel biosurfactants seems promising in pharmaceutical and personal care applications. Herein, we report the synthesis and interfacial properties of cholesterol based biocompatible surface-active biosurfactant choline cholate (CC) and choline deoxy cholate (CDC) surfactants, prepared through salt metathesis reaction. The surface activity and aggregation behavior of these surfactants were investigated by surface tension measurements and small angle X-ray scattering (SAXS) technique. CC and CDC both formed well-defined micelles with distinct CMC values as indicated by tensiometry, while the SAXS patterns can be well described by the polydisperse ellipsoid model. Furthermore, it was observed that both CC and CDC showed good foamability ascribed to the foam film rigidity which could be highly beneficial. Also, CC and CDC showed sphere-to rod micellar transition in the presence of CTAB. The study reported here may prove to be highly beneficial for pharmaceutical and personal care product formulations.