Organophosphorous phenyl phosphates: Synthesis, dye/protein interactions and antimicrobial evaluation

A series of Phenyl Phosphates (PPs) has been synthesized and characterized with FTIR spectroscopy. PPs, the product of the reaction of phenol and phosphoryl chloride followed by hydrolysis having larger number of hydrophilic hydroxyl groups, used for the dye interaction and antimicrobial activities. Interaction of PPs with 1,2-diphenyldiazene and 4-(phenyldiazene)phenol were studied through UV/ Vis method where observed hypochromic effect has revealed the dye adsorption property of PPs. Similarly PPs have shown the interaction with bovine serum and human serum albumins where the weaker interaction observed with later. Antimicrobial in vitro evaluation has been assessed on the basis of zone of inhibition with six bacterial (gram +ve and –ve) strains. Since PPs were found very active so minimal inhibitory concentration (MIC) analysis was done where all PPs have shown MIC less than 5 μg/mL. Due to high number of hydroxyl groups PPs have shown good interactions with biomolecules and cell wall of bacteria therefore this impression has predicted their future in medicinal field. [Display omitted] •Synthesis of Phenyl Phosphates (PPs) and characterization with FTIR spectroscopy.•Interaction of PPs with 1,2-diphenyldiazene and 4-(phenyldiazene)phenol through UV/ Vis method.•Observed hypochromic effect revealed the dye adsorption property of PPs.•Antimicrobial in vitro evaluation on the basis of zone of inhibition with six bacterial (gram +ve and –ve) strains.•Minimal inhibitory concentration analysis have shown less than 5 μg/m.