Cyclodextrin functionalized multi-layered MoS2 nanosheets and its biocidal activity against pathogenic bacteria and MCF-7 breast cancer cells: Synthesis, characterization and in-vitro biomedical evaluation

Recently, two-dimensional (2D) nanomaterials have received intensive attention in the field of nanotechnology. Among them, transition metal dichalcogenides (TMDs) showed enormous versatility in the field of biomedical applications. In particular, molybdenum disulfide (MoS2) based nanocomposites (NC) have been attracted by their superior physicochemical and biological properties. Here, we focus on the synthesis of highly biocompatible β-cyclodextrin (β-CD) functionalized MoS2 (β-CD/MoS2) hybrid NC by liquid exfoliated hydrothermal process and its structural, morphological, optical, and thermal properties were analyzed. Synthesized β-CD/MoS2 NC exhibits remarkable antibacterial activity against various clinical pathogens such as S. aureus and E. coli. Besides, 100 μg/mL of NC shows 34 and 40 mm of inhibition zone against S. aureus and E. coli respectively. Moreover, it showed 70.45% cell inhibition against MCF-7 breast cancer cells. In the future, synthesized NC will be a promising material in the field of biomedical cancer therapy and drug delivery. [Display omitted] •β-cyclodextrin-MoS2 NC was prepared by a liquid exfoliated hydrothermal method.•FTIR and XPS spectrum confirms the functionalization of β-cyclodextrin on MoS2.•SEM and TEM micrographs confirm MoS2 was formed as a multilayered 2D structure.•The functionalization of β-cyclodextrin enhances the biocompatibility of MoS2 NPs.•The NC highly inhibits the growth of bacterial and cancer pathogens.