Solubility of acetaminophen in (ethanol + propylene glycol + water) mixtures: Measurement, correlation, thermodynamics, and volumetric contribution at saturation

The equilibrium solubility at five temperatures from (293.15 to 313.15) K, apparent dissolution, mixing and solvation thermodynamics, and apparent specific volume at saturation of acetaminophen (ACP) in {ethanol (EtOH) (1) + propylene glycol (PG) (2) + water (3)} mixtures is reported. Mole fraction solubility of ACP (x4) increases when temperature arises and also increases with the EtOH and/or PG proportions increasing. It varies from x4 = 4.56 × 10−3 in the mixture 0.10–0.10-0.80 in mass fraction to x4 = 6.63 × 10−2 in the mixture 0.80-0.10-0.10 at 298.15 K. Solubility behavior was adequately correlated by Jouyban-Acree model and the obtained overall mean percentage deviations (MPD) of 4.0% (N = 330). Moreover, the trained Jouyban-Acree model using a minimum number of experimental data points predicted the rest of data points with the MPD of ~5.0% (N = 303). From the variation of solubility with temperature the apparent thermodynamic analysis of dissolution was performed in all the ternary mixtures. Further, from densities of the saturated solutions and those of the cosolvent mixtures free of drug, the apparent specific volumes at saturation were also calculated. •Solubility of acetaminophen in (ethanol + propylene glycol + water) mixtures at several temperatures is reported.•Dissolution, mixing and solvation apparent thermodynamic quantities are calculated.•Solubility data was correlated by means of Jouyban-Acree model.•Apparent specific volumes at saturation of acetaminophen were also calculated.