Platinum Nanoparticles/Nanodiamonds Nanocomposites with Enhanced Catalysis Activity for Sensitive Colourimetric Glucose Detection

A novel sensing strategy was developed by combining Pt-ONDs and gold bipyramids (AuBPs) for ultra-highly sensitive glucose detection, achieving a detection limit several thousand times lower than the lowest detection limit of commercial glucometers. [Display omitted] •Oxidation of nanodiamonds to prepare nanozymes.•Enhanced catalytic activity of platinum nanoparticles loaded on oxygenated nanodiamonds.•Exploration of gold bipyramids as sensing unit for the detection of glucose.•Detection of glucose with wide detection range and high sensitivity. Nanozymes with high catalytic efficiency have been widely investigated and studied in various fields. Compared with natural enzymes, nanozymes with enzyme-mimicking properties possess the advantages of low-cost, scalability, high stability, and tunable catalytic performance. In this paper, platinum nanoparticles loaded on oxygenated nanodiamonds (Pt-ONDs) were synthesised through a one-step method as a highly efficient nanozyme to mimic the function of peroxidase. Based on this, a novel sensing strategy was developed by combining Pt-ONDs and gold bipyramids (AuBPs) for sensitive detection of glucose. The detection limit of this method was established at 0.2 μM (a few thousand times before the lowest detection limit of commercial glucometers), with a wide detection range from 0.2 to 400 μM, highlighting its potential for ultra-high sensitive glucose detection. This study may provide a novel strategy for the application of nanozymes and gold nanostructures for the sensitive detection of glucose.