Novel electrochemical sensor based on MoS2NSs@AgNPs/MWCNTs-COOH nanocomposites for effective detection of Penciclovir

Material Preparation Methods and PCV Detection Roadmap. This illustration summarizes the use of uniform MoS2NSs as a scaffold for the growth of AgNPs to eliminate the stacking of MoS2 nanosheets and the aggregation of AgNPs. AgNPs were synthesized on MoS2NSs by in situ reduction, and then MWCNTs-COOH was compounded with the above two materials by ultrasonication to construct a PCV electrochemical sensing platform based on MoS2NSs@AgNPs/MWCNTs-COOH/GCE. The electrochemical behavior of PCV was investigated by linear scanning voltammetry (LSV) under optimal conditions. A new and simple electrochemical method for sensitive determination of PCV in drugs, urine, blood, and river water was proposed for low concentrations of PCV. [Display omitted] •First development of a PCV electrochemical sensing platform based on MoS2NSs@AgNPs/MWCNTs-COOH.•The synergistic effect of highly conductive AgNPs, large specific surface area MoS2NSs and MWCNTs-COOH improves the sensitivity of the sensor.•The sensor is capable of determining AMP over a wide linear range (0.5–200.0 µM) with a low detection limit (0.039 µM).•Sensors perform well in actual pharmaceuticals, urine, blood and river water samples. Abnormal levels of penciclovir (PCV) in humans may lead to inflammation and renal impairment, and its frequent detection in the aquatic environment poses environmental hazards. Consequently, timely detection and regulation of PCV concentrations in the human body are crucial for drug research, disease diagnosis, and environmental protection. In this study, a PCV electrochemical sensing platform based on MoS2NSs@AgNPs/MWCNTs-COOH was constructed by in situ reduction of silver nanoparticles (AgNPs) on MoS2 nanosheets (MoS2NSs) and complexed with carboxylated multi-walled carbon nanotubes (MWCNTs-COOH). The synergistic effect of highly conductive AgNPs, high surface area MoS2NSs, and MWCNTs-COOH increased the electron transfer rate at the electrode surface and thus effectively promoted the electrooxidation process of PCV. The electrochemical performance of the sensor was investigated and optimized by cyclic voltammetry (CV) and linear scanning voltammetry (LSV). The linear response of PCV under optimal conditions was in the range of 0.5–200.0 µM, with a limit of detection (LOD) of 0.039 µM (S/N = 3), and recoveries of 98.1–101.1 %, 95.6–101.6 %, 97.0–103.6 %, and 96.0–100.9 %. The results show that the constructed MoS2NSs@AgNPs/MWCNTs-COOH /GEC sensing platform has the advantages of high