A signal-on electrochemiluminescence (ECL) sensor based on luminol@carbon nanotubes and CdTe-ZnS@hydroxyapatite for the detection of paclitaxel

In this work, CdTe-ZnS was used as an ECL promoter to enhance the initial signal of luminol. Firstly, luminol@CNTs was modified on the surface of the electrode, and then CdTe-ZnS@HAP was modified on the upper layer of luminol@CNTs. The CNTs and HAP were used as carriers to enhance the stability and ECL intensity of the sensor. The successful preparation of CdTe-ZnS@HAP/luminol@CNTs/GCE was tested in a PBS solution (pH 8.0) and showed a certain luminescence. When the paclitaxel was added, the ECL signal was significantly enhanced. Based on the above phenomenon, a novel signal-on ECL sensor for the detection of paclitaxel was developed. [Display omitted] •A signal-on electrochemiluminescence sensor for the detection of paclitaxel was proposed.•Near-infrared CdTe-ZnS was prepared as a co-reaction promoter.•The electrochemiluminescence sensor had good stability and a low detection limit. A signal-on solid-state electrochemiluminescence (ECL) sensor based on luminol@carbon nanotubes (luminol@CNTs) and CdTe-ZnS@hydroxyapatite (CdTe-ZnS@HAP) was constructed for the detection of paclitaxel (PTX). In this sensing platform, luminol was used as the main luminophore and CdTe-ZnS was used as a co-reaction accelerator. CNTs and HAP were acted as carriers to adsorb more luminophores and co-reaction promoters. In addition, due to the enhanced effect of PTX on the ECL intensity of the luminol-O2 system, PTX was introduced as the final detection target. Under the optimal experimental conditions, the ECL intensity change values (ΔI) of the sensor showed a good linear relationship with the logarithm of PTX concentration in the range of 3 × 10-12 − 3 × 10-7 molL-1, and the limit of detection was 1 × 10-12 mol L-1(S/N = 3). This method was successfully applied to the determination of trace PTX concentration in serum.