Comprehensive overview of utilizing metal-organic frameworks (MOFs) for precise cancer drug delivery

[Display omitted] •Cancer is multifaceted and influenced by genetic and environmental variables, affecting health, society, and the economy.•Materials science advances, especially metal–organic frameworks (MOFs), have improved cancer detection, diagnosis, and treatment.•MOFs are adaptable carriers for medicinal chemicals and precise cancer cell targeting tools.•MOFs can release medicinal substances reactingto stimuli, enabling externally controlled cancer treatments.•It also addresses intelligent nanobiomaterials’ problems and possible uses in cancer treatment delivery systems. Cancer is a complex disease that develops due tocomplex interactions between hereditary and environmental variables. This devastating disease has far-reaching consequences for human health, communities, and the economy. Therefore, there is a pressing need to improve techniques for detecting, diagnosing, and treatingcancer. In recent times, the discipline of materials science has witnessed a significant advancement inmetal–organic frameworks, more frequently referred to as MOFs. Metal-organic frameworks (MOFs) have recently garnered considerable attention owing to their immense potential and adaptability in various applications. Notably, they have shown great promise as effective carriers for delivering therapeutic compounds and as precise tools fortargeting cancer cells. The intentional manipulation of metal–organic frameworks (MOFs) has endowed them with the distinct ability to selectively release pharmaceutical agents in response to particular stimuli. This attribute has significant potential for the development of externally controlled cancer treatments.Thisreview highlights the current developments in MOF synthesis, highlighting the unique properties that make MOFs ideal for therapeutic applications. We will delve deeply into the benefits of these innovations, focusing on how they can be used in cancer therapy. We will also closely examinetheir challengesand the potential future applications of intelligent nanobiomaterials in cancer medicine delivery systems.