Design of an electrochemical sensing platform based on MoS2-PEDOT:PSS nanocomposite for the detection of epirubicin in biological samples

[Display omitted] •It is the first time that CE-MoS2/PEDOT:PSS nanocomposite was synthesized and used as an analytical platform.•CE-MoS2/PEDOT:PSS/SPCE demonstrated a good electrocatalytic activity and sensing performance towards the detection of EPB.•The applicability of CE-MoS2/PEDOT:PSS/SPCE was successfully tested by the determination of EPB in human plasma sample.•CE-MoS2/PEDOT:PSS/SPCE could be a portable platform for monitoring and determination of anthracycline antibiotics. Synthesizing of two dimensional (2D)-based nanomaterial and its sensing platform design is an attractive approach for quantitative purposed electrochemical applications. In this work, for the first time, we synthesized the molybdenum disulphide (CE-MoS2) nanosheets exfoliated by metal intercalation method and followed by the modification of their surfaces with Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) as a conductive polymer. The structural, morphological, and electrochemical characterization of CE-MoS2/PEDOT:PSS nanocomposite were performed by XPS, TGA, TEM and EIS. The portable electrochemical sensing platform was fabricated by the modification of CE-MoS2/PEDOT:PSS nanocomposite on screen-printed carbon electrode (SPCE). The electrochemical behaviour of epirubicin (EPB) was examined on SPCE modified with CE-MoS2/PEDOT:PSS nanocomposite using cyclic and differential pulse voltammetry. CE-MoS2/PEDOT:PSS/SPCE demonstrated a promising electrocatalytic activity towards the oxidation of EPB, and analytical performance in the concentration range of 0.06 – 9.30 µM with a low detection limit of 44.3 nM. The human plasma samples containing EPB were successfully analyzed using CE-MoS2/PEDOT:PSS/SPCE with the satisfactory recoveries. The proposed sensing design could be an alternative strategy to produce the 2D-based nanoplatforms for electroanalytical applications in clinical samples.