Highly sensitive amperometric determination of chlorpromazine hydrochloride in blood serum sample employing antimony vanadate nanospheres as electrode modifier

Antimony Vanadate Nanospheres as Electrode Modifier for Sensitive Amperometric Determination of Chlorpromazine Hydrochloride in Blood Serum sample. [Display omitted] •Facile synthesis of SbVO4 microspheres through the hydrothermal method.•Fabrication of SbVO4modified GCE with improved electrochemical performance.•Amperometry determination of Chlorpromazine hydrochloride with remarkable LOD (0.11 nM).•Feasibility of fabricated sensor explored in the blood serum sample. Chlorpromazine hydrochloride (CPH) is an antipsychotic medication that is premeditated for the treatment of psychiatric disorders, particularly the diminution of states of anxiety and tension. Regardless of its prevalent use as a prescribed suppository chronic use of these neuroleptics produces several worsened side effects at its overdosage which include cognitive and psychomotor impairment. An instantaneous detection system is indispensable to consider the physiological impact of these drugs in a biological medium. The main objective of this work emphasizes developing a sensing platform for the detection of CPH using an eminent electrode modifier to enhance the performance of traditional glassy carbon electrodes. To accomplish the intention antimony vanadate (SbVO4) microspheres have been synthesized through a hydrothermal approach and proceeded with structural and morphological characterization to authenticate the successful preparation. Further, the prepared electrocatalyst has been used to fabricate the SbVO4/GCE platform which could afford a wide linear range of 0.0012–163.30 μM with a remarkably low limit of detection of 0.11 nM, and appreciable sensitivity of 0.00167 µA⋅µM−1⋅cm−2 with antiinterferring ability and virtuous stability. Furthermore, a tentative study on extending the fabricated sensor to the blood serum matrix is successful by achieving a low limit of detection of 0.14 nM.