A highly selective and sensitive electrochemical sensor based on graphene oxide and molecularly imprinted polymer magnetic nanocomposite for patulin determination

[Display omitted] •The of fabrication MIP/Fe3O4/GO nanocomposite through non-covalent imprinting process.•The preparation of the MIP/ Fe3O4 /GO modified glassy paste electrode.•Electrochemical detection of patulin by square wave voltammetry and cyclic voltammetry techniques.•A novel selective and sensitive sensor with excellent merit figures for patulin determination in apple juice. Since a high concentration of patulin is caused cytotoxic, the detection of a novel approach for patulin determination plays an important guiding role in the research and development of new control technologies. For the first time, we have developed a novel sensor using a glassy carbon electrode modified by a composite consisting of ionic liquid-based molecularly imprinted polymer (MIP) and magnetic nanoparticles/graphene oxide (Fe3O4/GO) for the determination of patulin toxin using square wave voltammetry technique. The nanostructures were prepared and characterized with scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and energy dispersive X-ray spectroscopy (EDX) techniques. Several experimental parameters affecting the patulin determination, such as scan rate, the type, and pH of buffer solution, were studied and optimized. Under the optimized conditions, a linear range of 0.001 nM − 250.0 nM, a limit of quantification of 0.001 nM and a limit of detection of 3.33×10-4 nM was obtained. The RSDs for 1.0 nM and 250.0 nM patulin were calculate 1.65 % and 0.83%, respectively. The MIP/Fe3O4/GO/GCE was successfully applied to detect patulin toxin in apple juice real samples.