Solid-liquid-solid conversion microextraction combined with high-performance liquid chromatography for determination of bisphenols

•The application of stimulus-responsive polymer as a green alternative extractant.•The extractant can be completely dissolved in the solution without auxiliary means.•The extractant can be quickly separated from the solution by changing temperature.•The developed method is fast, simple, sensitive and environmentally friendly. A novel solid-liquid-solid conversion microextraction combined with high-performance liquid chromatography method (SLSC-ME-HPLC-UV) has been developed to preconcentrate trace bisphenols (BPs) in environmental water, in which poly (isopropyl acrylamide-co-methyl methacrylate) P(MMA-co-NIPAM) was used as the extractant. The hydrogen bond and hydrophobic interaction play an important role between the P(MMA-co-NIPAM) and BPs. The ratio of copolymer MMA to NIPAM monomers, type and concentration of salt, extraction time and acetonitrile volume, as variables affecting the efficiency of extraction process, were investigated with the aid of single-variable optimization. Under optimal conditions, the coefficient of determination (R2) of calibration curves was greater than 0.999. Enrichment factors (EFs) ranged from 74 to 128. Extraction recoveries (ERs) ranged from 44 to 77%. The limits of detection (LODs) and limits of quantification (LOQs) were in the ranges of 0.20–0.90 and 0.68–3.01 μg L−1, respectively. The values for intra-day and inter-day precisions were lower than 3.6% and 3.3%, respectively.