Study of the potential association of the BCHE rs1803274 genetic polymorphism and serum level of its protein with breast cancer

Genetic-based individual differences remain a promising area for studying cancer susceptibility. BCHE gene encodes the butyrylcholinesterase (BChE) enzyme, which has been linked to inflammation and tumor genesis. The commonest missense mutation of BCHE gene is the rs1803274 G/A polymorphism. We aimed to analyze BCHE rs1803274 gene polymorphism in terms of distribution among breast cancer patients, its effect on enzyme activity and its correlation with clinic pathological parameters. 160 breast cancer female patients matched by age with 120 female healthy controls were recruited. CA 15–3 and CEA were measured by ELISA. BChE activity was measured by spectrophotometry. BCHE rs1803274 polymorphism was analyzed by real time- PCR. Significant higher prevalence of GA genotype and A allele were observed in patients [P