Association analysis of premature coronary artery disease and cytochrome P450 2D6 (CYP2D6) C100T and G1846A genetic variants and haplotypes in Iranian population

Premature coronary artery disease (pCAD) is a heterogeneous disease affected by both genetic and environmental determinants. Cytochrome P450 2D6 (CYP2D6) enzyme plays an important role in the oxidation of drugs and inactivation of reactive species. Therefore, polymorphisms in CYP2D6 may lead to an increased susceptibility to pCAD. Here, we analyzed the association between C100T and G1846A polymorphisms of CYP2D6 gene with pCAD in a south Iranian population. Men under 45 and women under 55 years old enrolled in this study as 168 pCAD patients and 167 controls. Clinical characteristics of participants were assessed thorough clinical examination. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied for C100T and G1846A polymorphisms. The results indicated that the history of smoking and hypertension were significantly associated with the incidence of pCAD (p