Occurrence of +874T/A gene polymorphism of interferon-gamma in Iraqi atopic patients

Traditionally, asthma, atopic dermatitis and allergic rhinitis, in addition to food allergy, categorized as atopic diseases, the term allergy refer to immediate hypersensitivity which used to describe the combined immediate and late phase reactions. This study aimed to determine serum total IgE level, eosinophil count, and serum level of IFN-γ, in relation to the age of atopic patients and genotyping of the IFN-γ gene at +874 T/A in relation to serum IFN-γ level. As well as comparing of IFN-γ concentrations of atopic patients according to genotypes in atopic patients and apparently healthy control. The studied groups were 25 apparently healthy controls and 75 atopic patients (25 asthma patients, 25 allergic rhinitis patients and 25 atopic dermatitis patients). The obtained results showed that, the prevalence of atopic diseases occurred in the age group between 21 and 40 (second group) are more than the age group less than 21 (first group) and the age group of more than 40, third group (p = .0001). Moreover, total IgE is significantly increased in the three atopic groups compare to control (P