Association of FCRL3 rs7528684 polymorphism with risk of Hashimoto's thyroiditis in Iranian patients

Hashimoto's thyroiditis (HT) is an autoimmune disorder of thyroid gland characterized by loss of thyroid functions and structure. Accumulation of lymphocytes and other immune mediators is a preliminary step in HT development. Fc receptor-like (FCRL)-3 gene have recently shown a significant asso...

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Veröffentlicht in:Meta Gene 2020-06, Vol.24, p.100663, Article 100663
Hauptverfasser: Kalantar, Kurosh, Ghandehari, Farzad, Malek-Hosseini, Saeed, Golmoghaddam, Hossein, Rostamzadeh, Davood, Dabbaghmanesh, Mohamad Hossein, Amirghofran, Zahra
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Sprache:eng
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Zusammenfassung:Hashimoto's thyroiditis (HT) is an autoimmune disorder of thyroid gland characterized by loss of thyroid functions and structure. Accumulation of lymphocytes and other immune mediators is a preliminary step in HT development. Fc receptor-like (FCRL)-3 gene have recently shown a significant association with HT. The aim of this study was to evaluate the FCRL3 single nucleotide polymorphisms (SNPs), rs7528684 and rs11264799, in Iranian patients with HT. Genomic DNA was extracted from whole blood of 322 individuals with HT and 302 healthy individuals. The FCRL3 gene rs7528684 and rs11264799 SNPs were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We found that the rs7528684 SNP was statistically associated with risk of HT. In patients, the frequencies of CC genotype and C allele were significantly higher than healthy controls (CC vs. TT + CT, OR = 2.33, 95% CI = 1.57–3.46, p 
ISSN:2214-5400
2214-5400
DOI:10.1016/j.mgene.2020.100663