The hypothetical molecular pathways of ursolic acid to attenuate the premature ovarian failure in human

Premature ovarian failure, which is also called premature menopause, refers to the stop of menstruation and the formation of oocyte before 40 years old. As a disease which is closely related to the formation of oocyte and relevant meiosis, the role of adjacent cells such as ovarian granulosa cell or the membranous follicular cells in the pathogenesis of premature ovarian failure is currently being investigated. One of the most popular theories concludes that premature ovarian failure is due to the apoptosis of the ovarian granulosa cells, as they are responsible for the synthesis and regulation of multiple types of hormones and internal factors that are related to reproduction, for example, the inhibin, activin, and follistatin. The apoptosis of the ovarian granulosa cells can be initiated by various of internal or external environmental factors such as the hazardous chemicals in the ovarian or the excessive exposure to the physical radiation as a result of the occupation. While the detailed underlying mechanisms to cause the apoptosis of the ovarian granulosa cell are still unclear. The ursolic acid is white concrete at room temperature, and many studies have elucidated that it can relieve hypoxia and endoplasmic reticulum stress. In this article, the author proposed five molecular pathways of ursolic acid to relieve or cure premature ovarian failure in humans.