Silk fibroin infilled 3D printed polymer-ceramic scaffold to enhance cell adhesion and cell viability

•Polymer-ceramic hybrid 3D printed scaffold.•Presence of calcium, phosphate, and magnesium ions improves the mechanical and physical properties.•The infilling of silk fibroin (SF) in the 3D printed scaffold are observed to improve the biological activity.•The entrapped cells in the SF infilled regions could enhance the regeneration process. 3D printing technology has been a remarkably convincing strategy for fabricating scaffolds that can be used as a replacement for damaged tissue, which could help in regeneration and vascularization. In this study, polymer-ceramic composite 3D-printed scaffolds [Polycaprolactone(PCL), Hydroxyapatite(HAP) and Magnesium hydroxide(Mg(OH)2)] were fabricated, and infilled with silk fibroin(SF) to increase the cell adhesion in the scaffold. The cell adhesion was investigated by SEM analysis. It was observed that the presence of silk fibroin in the infilled region improves cell adhesion and cell viability; however, there was no significant difference in mechanical strength between SF-PCL Composite and PCL Composite, which were found to be 3.1 MPa and 2.92 MPa, respectively.