Trivalent rare earth elements substitution in 58S bioactive glass matrix for bone repair applications - An in vitro and in vivo study

The development of bone grafts and prosthetic implants for clinical need is still difficult due to the complexity of integrated physiological processes. The 58S glass ceramic is one of the most widely accepted biomaterial for preparing hard tissue damages due to its capability to react at molecular level. On the other hand, 58S glass ceramic are suffers some extent to expedite the new bone formation. The incorporation of rare earth elements into the bioactive glass ceramic matrix significantly improved the new bone formation. In addition, the cytotoxicity and biocompatibility properties of the obtained ceramic powder were investigated in vitro and in vivo for bone graft efficiency. The results showed that the rare earth elements in bioactive glass ceramic have the potential to repair damaged hard tissues. •Adoption of Sol-gel chemistry to synthesis glass ceramic.•Choice of rare earth elements as substituents.•Hemolytic evaluation of the developed material.•In vitro cell proliferation studies on the synthesized material.•In viva animal experiments to evaluate the suitability of the developed biomaterial for orthopedic applications.