Phosphorylation of Ser1452 on BRG1 inhibits the function of the SWI/SNF complex in chromatin activation

Phosphorylation of Ser1452 on BRG1 inhibits the function of the SWI/SNF complex in chromatin activation

BRG1, one of core subunits of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancers. Previously, we reported significant downregulation of the phosphorylation level of BRG1 on Ser1452 (

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Veröffentlicht in:Journal of proteomics 2021-09, Vol.247, p.104319, Article 104319
Hauptverfasser: Kimura, Ayuko, Arakawa, Noriaki, Kagawa, Hiroyuki, Kimura, Yayoi, Hirano, Hisashi
Format: Artikel
Sprache:eng
Schlagworte:
BRG1
Linker histone
Ovarian cancer
Phosphorylation
SWI/SNF complex
Ubiquitin
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Beschreibung
Zusammenfassung:BRG1, one of core subunits of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancers. Previously, we reported significant downregulation of the phosphorylation level of BRG1 on Ser1452 (
ISSN:1874-3919
DOI:10.1016/j.jprot.2021.104319