Efficient fluorescence probe for detection of naproxen in pharmaceutical formulations and water samples using MPA-capped CdTe/ZnS core-shell nanocrystal-neutral red: Experimental and computational studies

The response mechanism of the proposed fluorescent probe for the determination of naproxen was illustrated. Initially, the fluorescence intensity of MPA-TGA-CdTe/ZnS core/shell QDs was quenched by neutral red (NR) to create a fluorescence “OFF–ON” probe. Following the addition of naproxen, the high...

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Veröffentlicht in:Journal of photochemistry and photobiology. A, Chemistry. Chemistry., 2024-07, Vol.452, p.115545, Article 115545
Hauptverfasser: Shokri, Tahereh, Sadeghi, Marzieh, Hadidi, Saba, Mohammadi, Soheila
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Sprache:eng
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Zusammenfassung:The response mechanism of the proposed fluorescent probe for the determination of naproxen was illustrated. Initially, the fluorescence intensity of MPA-TGA-CdTe/ZnS core/shell QDs was quenched by neutral red (NR) to create a fluorescence “OFF–ON” probe. Following the addition of naproxen, the high affinity between NR and NAP caused them to move away from the MPA-TGA-CdTe/ZnS QDs surface, forming an NR-NAP complex, which resulted in the restoration of the fluorescence intensity of MPA-TGA-CdTe/ZnS QDs. [Display omitted] •MPA -capped CdTe/ZnS QDs as a selective turn OFF-ON fluorescence probe for detection of naproxen was prepared.•Interactions mechanisms ofnaproxen, neutral red andMPA-capped CdTe/ZnS-quantum dotswere investigated by various spectroscopic and computational studies.•The turn OFF-ON flourescence probe allowed us to achieve highly sensitive and accurate results with a very low detection limit (0.07 µmol/L). The distinct optical properties of surface-engineered quantum dots, featuring high fluorescent quantum yields and biocompatibility, render them valuable tools for precise and selective sensing and biosensing applications spanning diverse fields, including medicine, environmental monitoring, and diagnostics. In this study, we have successfully fabricated a new “OFF-ON” fluorescent probe based on 3-mercaptopropionic acid (MPA) - capped CdTe/ZnS QDs and neutral red (NR) for the determination of Naproxen (NAP) in pharmaceutical formulations and water samples. The as-prepared MPA-TGA-CdTe/ZnS QDs exhibit a robust photoluminescent emission, peaking at 544 nm upon excitation with a 380 nm wavelength. The quantum yield measurement for the TGA-CdTe QDs was ascertained to be 29.3 %. The findings displayed that the fluorescence emission of MPA-TGA-CdTe/ZnS quantum dots (QDs) could be significantly quenched by increasing neutral red concentration, which can be attributed to the formation of non-fluorescent NR- MPA-TGA-CdTe/ZnS QDs complex (NR-MPA energy level 1.15 Kcal/mol). Upon the addition of naproxen, there was a noticeable enhancement in fluorescence intensity because of the formation of the strong complex between naproxen and NR (NR-NAP energy level: −1.54 Kcal/mol), leading to the detachment of NR from the surface of quantum dots. Consequently, the MPA-TGA-CdTe/ZnS QDs became activated, resulting in the restoration of fluorescence intensity of MPA-TGA-CdTe/ZnS QDs. The enhancement of fluorescence intensity exhibited a direct relationship with the
ISSN:1010-6030
1873-2666
DOI:10.1016/j.jphotochem.2024.115545