Covalent synthesis, structural characterization and biological behavioral study of tin captured porphyrin-polyoxometalate based polymeric hybrid

[Display omitted] •The synthesis of Polyoxometalate polymeric hybrid from newly synthesized tin based porphyrin which were evaluated for drug delivery, DNA binding, protein binding and antibacterial studies.•It is found that drug loading efficiency was 89% and 93% for PolySnP@POM and SnTPP-Di-Tris, respectively.•Uv–visible study of SnTPP-Di-Tris and PolySnP@POM with salmon sperm DNA (SS-DNA) showed hypochromism trend which indicate intercalation mode of attachment.•Protein binding Study presented binding constant value (Kb) 3.09 × 104 M−1 and 1.30 × 104 M−1 for PolySnP@POM, and SnTPP-Di-Tris, correspondingly.•Antibacterial activity results showed minor to significant activity. The combination of polyoxometalates(POMs) and tin-based porphyrin in a variety of modes ofinteractionturned out to be the key for unlocking new directions in the study of biological activities. In this study, a new sandwich type covalently attached porphyrin C52H48N6O6Sn (SnTPP-Di-Tris) and Anderson POM-porphyrin polymeric hybrid, with molecular formula as [{N(C4H9)4}8{C62H60Mn2Mo12N6O48Sn·CH3CN}](PolySnP@POM). These compounds were clearly characterized and their formation was confirmed by spectroscopic (UV–visible, FT-IR, NMR) techniques, powder XRD, elemental analyses, cyclic voltammetry and scanning electron microscopy techniques(SEM). SnTPP-Di-Tris and PolySnP@POM were evaluated for drug delivery, DNA binding, protein binding and antibacterial studies. It is found that drug loading efficiency was 89% and 93% for PolySnP@POM and SnTPP-Di-Tris, respectively. While drug release was more efficient in acidic media (pH = 3) as 100 % for both compounds in 1.5 h as compared to basic media (pH = 11) 65.93% and 72.6% for SnTPP-Di-Tris and PolySnP@POM, respectively. Uv–visible study of SnTPP-Di-Tris and PolySnP@POM with salmon sperm DNA (SS-DNA) showed hypochromism trend which indicate intercalation mode of attachment and exhibited binding constant value 4.9 × 103 M−1 and 2.7 × 104 M−1 for SnTPP-Di-Tris and PolySnP@POM, respectively, referring that PolySnP@POM has more binding affinity than SnTPP-Di-Tris. Protein binding Study presented binding constant value (Kb) 3.09 × 104 M−1 and 1.30 × 104 M−1 for PolySnP@POM, and SnTPP-Di-Tris, correspondingly. Antibacterial activity results showed minor to significant activity. Furthermore, enhanced antibacterial activity of SnTPP-Di-Tris over its corresponding hybrid PolySnP@POM was observed because of lipophilic and more proliferating nature of SnTP