Fabrication of Cupric oxide decorated β-cyclodextrin nanocomposite solubilized Nafion as a high performance electrochemical sensor for l-tyrosine detection

In the present work, a novel cupric oxide decorated on β-cyclodextrin (CuO/β-CD) nanocomposite was synthesized by sonochemical method. The CuO/β-CD nanocomposites were characterized by UV–vis, Raman, FT-IR, FE-SEM, mapping analysis, XRD techniques. Fascinatingly, the CuO/β-CD nanocomposite Nafion (Nf) solubilized modified glassy carbon electrode (CuO/β-CD/Nf/GCE) has exhibited a superior electrocatalytic activity towards the l-tyrosine, when compared to the modified β-CD, CuO, and bare GCE electrodes. Besides, the electrochemical sensing performance was revealed as an excellent amperometric i-t current response for the l-tyrosine determination with a wide linear range from 0.01 to 100 μM, high sensitivity 442 μA μM−1cm2 and low detection limit (LOD) 0.0082 μM. Furthermore, it manifested a good selectivity, repeatability, stability, and reproducibility. In addition, the CuO/β-CD/Nf modified GCE electrode shows good sensibleness for the l-tyrosine detection of blood serum, food samples, and urine samples. [Display omitted] •Cupric oxide decorated β-cyclodextrin nanocomposite was synthesized using sonochemical method.•Cupric oxide decorated β-cyclodextrin nanocomposite shows enhanced electrocatalytic detection of l-tyrosine.•It is owing to better electron transfer efficiency and high surface area of the nanocomposite modified electrode.•Amperometric technique is adopted to identify low detection of l-tyrosine in the presence of real samples.