Novel drug delivery to the brain for neurodegenerative disorder treatment using carbon nanotubes
Neurodegenerative disorders pose a significant challenge in drug delivery because of the substantial obstacle presented by the blood–brain barrier (BBB). Conventional therapeutic agents frequently encounter constraints in efficiently penetrating the brain, thus requiring inventive delivery strategie...
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Veröffentlicht in: | Journal of King Saud University. Science 2024-12, Vol.36 (11), p.103513, Article 103513 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Neurodegenerative disorders pose a significant challenge in drug delivery because of the substantial obstacle presented by the blood–brain barrier (BBB). Conventional therapeutic agents frequently encounter constraints in efficiently penetrating the brain, thus requiring inventive delivery strategies. This review explores the potential aspects of the carbon nanotubes (CNTs) as an advanced drug delivery system for treating neurodegenerative disorders. CNTs, with their distinctive structural and physicochemical characteristics, present an intriguing framework for addressing challenges related to drug delivery across the BBB. The review emphasizes the functionalization of CNTs, utilizing diverse chemical modification techniques to improve their biocompatibility and effectiveness as drug carriers. The variations have a significant effect on crucial factors related to the growth of neurons.
Moreover, the review emphasizes the therapeutic ability of CNTs in treating neurodegenerative disorders. By introducing purified CNT substrates, an increase in the growth of dendrites and improved adhesion of hippocampal neurons was reported. This has led to significant progress in the processing of neuronal signals and the development of neural circuits. Finally, this review offers in-depth understanding of the innovative and enhanced nano-scaffolds provided by CNTs for transporting therapeutic substances to the brain. This offers potential for more efficient treatments for neurodegenerative disorders. |
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ISSN: | 1018-3647 |
DOI: | 10.1016/j.jksus.2024.103513 |