A Cu(II) coordination polymer: Crystal structure and therapeutic effect on sepsis

Unique thiocyanate-connected 1-dimensional chain Cu(II) coordination polymer (CP), namely, [Cu2L1(μ1,3-SCN) (η1SCN)]n (1), was produced in the existence of KSCN and Cu(NO3)2·3H2O utilizing an underlying multisite N,O donor Schiff base ligand (L1H2). [N,N′-bis(3-methoxysalicylidenimino)-1,3-daminopropane] (L1H2), the Schiff base ligand is a 1:2 M ratio condensation product of 1,3-diaminopropane and O-vaniline in the methanol medium. The as-created CP 1 has been investigated with various characterization approaches like powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FT-IR), elemental analysis (EA), -thermogravimetric analysis (TGA) and single crystal X-ray diffraction (SCXRD) analyses. And the mechanism and therapeutic effect of this CP on sepsis was discussed and its specific mechanism was also assessed. First of all, for the infected animals, their survival rate was recorded after the bacterial infection and treatment of complex. Besides this, utilizing the enzyme linked immunosorbent assay (ELISA) assay, the inflammatory cytokines levels that released into plasma were determined after the exposure of compound. [Display omitted]