Desorption of pharmaceuticals from pristine and aged polystyrene microplastics under simulated gastrointestinal conditions

[Display omitted] •Desorption of pharmaceuticals from PS microplastics was enhanced in digestive condition.•Increased desorption in stomach mainly depended on the competitive adsorption of pepsin.•High desorption in gut relied on the solubilization and competition of intestinal components.•Aging suppressed the desorption by changing the interaction of PS with pharmaceuticals.•Microplastic-associated pharmaceuticals posed low risks to marine organisms. Microplastics (MPs) in the environment usually undergo extensive weathering and can transport pollutants to organisms once being ingested. However, the transportation mechanism and effect of aging process are poorly understood. This study systematically investigated the desorption mechanisms of pharmaceuticals from pristine and aged polystyrene (PS) MPs under simulated gastric and intestinal conditions of marine organisms. Results showed that the increased desorption in stomach mainly depended on the solubilization of pepsin to pharmaceuticals and the competition for sorption sites on MPs via π-π and hydrophobic interactions. However, high desorption in gut relied on the solubilization of intestinal components (i.e. bovine serum albumin (BSA) and bile salts (NaT)) and the competitive sorption of NaT since the enhanced solubility increased the partition of pharmaceuticals in aqueous phase. Aging process suppressed the desorption of pharmaceuticals because aging decreased hydrophobic and π-π interactions but increased electrostatic interaction between aged MPs and pharmaceuticals, which became less affected by gastrointestinal components. Risk assessment indicated that the MP-associated pharmaceuticals posed low risks to organisms, and warm-blooded organisms suffered relatively higher risks than cold-blooded ones. This study reveals important information to understand the ecological risks of co-existed MPs and pollutants in the environment.