Syntheses of α-monofluoroalkyl acetophenones from fluoroalkyl carboxylic NHPI esters and silyl enol ethers by photocatalytic decarboxylative reaction

•α-monofluoroalkyl carboxylic NHPI Esters were employed as α-monofluoroalkylation radical reagents.•A series of α-monofluoroalkyl acetophenones were produced via photoredox-catalyzed decarboxylative α-monofluoroalkylation of silyl enol ethers in modest to good yields.•The method was applied to synthesize antalgic activity compound containing α-monofluoroalkyl acetophenone skeleton. A photoredox-catalyzed decarboxylative α-monofluoroalkylation of silyl enol ethers with fluoroalkyl carboxylic N-(hydroxy)phthalimide esters has been successfully developed. Diverse functionalized α-monofluoroalkyl acetophenones were produced in modest to good yields under mild and operationally simple conditions. The developed method was further applied to synthesize antalgic and ataractic activity compound containing α-monofluoroalkyl acetophenone skeleton. [Display omitted]