Determination of albendazole and ivermectin residues in cattle and poultry-derived samples from India by micellar liquid chromatography

•Albendazole and ivermectin were found in bovine dairy products and waste; and poultry edible tissues.•The developed method was reliable, easy-to-handle, safe, ecofriendly and low-cost.•This analytical procedure is suitable as screening method.•Some samples contained albendazole and ivermectin over...

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Veröffentlicht in:Journal of food composition and analysis 2021-10, Vol.103, p.104111, Article 104111
Hauptverfasser: Pawar, Rajendra-Prasad, Durgbanshi, Abhilasha, Bose, Devasish, Peris-Vicente, Juan, Albiol-Chiva, Jaume, Esteve-Romero, Josep, Carda-Broch, Samuel
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Sprache:eng
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Zusammenfassung:•Albendazole and ivermectin were found in bovine dairy products and waste; and poultry edible tissues.•The developed method was reliable, easy-to-handle, safe, ecofriendly and low-cost.•This analytical procedure is suitable as screening method.•Some samples contained albendazole and ivermectin over the permissible limits.•Several producers misadministrate the anthelmintic drugs to the animals. We have developed a method, based on micellar liquid chromatography, to determine albendazole and ivermectin in dairy products and biological waste from bovine, as well as edible tissues from poultry. Anthelmitics were resolved in less than 10 min using a C18 column and a mobile phase of 0.15 mol/L sodium dodecyl sulfate – 6% 1-pentanol at buffered at pH 7 with a 0.01 M phosphate salt, running under isocratic mode at 1 mL/min. Detection was by absorbance at 292 nm. Method was successfully validated following official validation guidelines, in terms of: selectivity, sensitivity, calibration range (0.0125−0.5 mg/kg to 25−50 mg/kg), linearity (r2 > 9990), trueness (86.3–105.6%), precision (
ISSN:0889-1575
1096-0481
DOI:10.1016/j.jfca.2021.104111