Thermo sensitive and pH responsive surface modulated transdermal green tea nanogel: Structural, physiochemical and in vitro safety investigations

An altered simplistic biomimetic whole green tea extract-loaded nanogel (GE-C-NGL) was fabricated possessing pH-responsive and temperature-dependent intracellular transdermal nanotherapy. A biocompatible chitosan nanogel subsequently surface modified with oleic acid aiding Pluronic 127 discharging green tea extract on transdermal delivery was evaluated in light of structural, physiochemical, thermal, and in vitro toxicological factors by optical class, index class and spectrophotometrically class, and in vitro cell line toxicological evaluations, which precisely elaborated the nanosize particle size range and significant drug entrapment suggesting a spherical and thermo stable nanogel system. Additionally, sustained drug release configuration is displayed in mildly acidic conditions (pH 6) signifying ultra-pH sensitivity of GE-C-NGL. Moreover, strong mucin binding ability, pH-dependent swelling efficiency, negligible hemolytic ratio, and high antioxidant activity were obtained for enhanced transdermal efficacy. The comprehensive augmented polymeric blend transdermal nanogel, in light of the above preclinical biological and toxicological evaluations, evidently targets transdermal potential with promising bacterial biodegradable nanodrug therapy in clinical platforms. [Display omitted]