Nanoinformatics and nanotechnology in anti-inflammatory therapy: A review

A necessary immune response that promotes survival and preserves tissue homeostasis, inflammation is a frequent characteristic of many disorders. In other circumstances, however, the inflammatory process turns harmful and aids in the progression of a disease. The use of nanomedicines (nanoparticles that are loaded with a therapeutic active principle) to target inflammation through the identification of molecules overexpressed on the surface of activated macrophages or endothelial cells, through increased vasculature permeability, or even through biomimicry offers a promising treatment for inflammatory diseases. The present review study will discuss the main novel nanomedicine approaches, nanoinformatics used in drug discovery and nanomedicine development and also the impact of nanoinformatics on different sectors of healthcare research that have been proposed in the previous decades for the resolution of inflammatory disorders after giving a brief overview of the pathophysiology of inflammation and current therapeutic approaches. It will then concentrate on those currently in clinical trials and ethical considerations. The nanomedicines, along with nanoinformatics, could help to improve delivery efficiency. The nanoinformatics can play a critical role in accelerating research and development in nanomedicine. We suggest that the application of nanoinformatics in this field can lead to novel breakthroughs, better understanding of underlying mechanisms, and ultimately drive innovation. In particular, we observe a potential for the use of nanoinformatics in drug design, delivery systems, and diagnostics. By leveraging the power of data-driven approaches, computational modelling, and artificial intelligence, we can unlock the full potential of nanomedicine and transform the way we approach healthcare. [Display omitted]