Recent trends in the delivery of plant-derived phytochemicals against various cancers using Nanotechnological approach: A comprehensive review

In the current scenario, treatment of killer disease cancer using conventional chemotherapeutical modalities, including surgery, immunotherapy, and radiotherapy has not been well established due to its number of limitations. Intolerable systemic adverse effects, damaging healthy tissue, structural deformities, drug resistance along with psychological problems associated with the mentioned conventional therapy withdraw the attention of many researchers to mitigate it. Hopefully, naturally occurring phytochemicals are immensely exploited for their pharmacotherapeutic use against devastating disease cancer. However poor pharmaceutical attributes including poor solubility, poor absorption, and hence low bioavailability, low stability, and bio-enzymatical degradability, stands as a major barrier against its clinical use. Nevertheless, Nanotechnological strategies having the capability to overcome the obstacles encountered during both conventional chemo and herbal therapy facilitate the steadily concentrate on the field of oncology. This review comprehensively focuses on the development of numerous nano-carriers for the targeted delivery of phytoconstituents against various cancers. [Display omitted]