QbD assisted formulation design and optimization of thiol pectin based Polyethyleneglycol and Montmorillonite(PEG/MMT) nanocomposite films of neomycin sulphate for wound healing

Skin wound healing, especially for chronic sores like diabetic foot ulcers, is still a medical emergency. Despite the abundance of treatment techniques that are currently accessible, none appear to be both effective and secure. In this context, we have emphasized the benefits of using clay and biopo...

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Veröffentlicht in:Journal of drug delivery science and technology 2023-04, Vol.82, p.104348, Article 104348
Hauptverfasser: Raghavendra Naveen, N., Anitha, Posina, Gowthami, B., Goudanavar, Prakash, Fattepur, Santosh
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Sprache:eng
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Zusammenfassung:Skin wound healing, especially for chronic sores like diabetic foot ulcers, is still a medical emergency. Despite the abundance of treatment techniques that are currently accessible, none appear to be both effective and secure. In this context, we have emphasized the benefits of using clay and biopolymers to create nano-drug delivery systems. Pectin was thiolated (TFP) followed by the formulation of neomycin sulphate nanocomposites using polyethylene glycol and montmorillonite (PEG/MMT) to accelerate wound healing. Box-Behnken design optimized Nano composite preparation by considering concentrations of TFP, PEG and MMT as process variables. Based on the desirability approach (d=1), formulation containing coded values of MMT-0.91; PEG-0.99, and TFP of -0.71 can achieve the prerequisites of the optimum formulation. Optimized nanocomposite formulation was further formulated into nanocomposite film (ONCF) and evaluated for mechanical properties, drug release, cytotoxic, and in vitro wound healing capabilities. OCNF had no cytotoxic effects, as evident from the more than 90% survival rate of C6 glioma cells. In vitro wound, healing activities prove that composite-to-film conversion will be responsible for most antioxidant activity. In vivo wound healing and histomorphometry studies demonstrate the formulation's efficacy in wound healing. Therefore, the TFP-PEG/MMT nanocomposite film is of great potential in the biomedical field. [Display omitted] •Till date, NO comprehensive research exists or has been published on complimenting Polyethyleneglycol and Montmorillonite (PEG/MMT) nanocomposite films for neomycin sulphate.•No similar research publication has been found on conversion of nanocomposites into films for wound healing.•The research will be a milestone in the application of Quality by Design in the ddevelopment of nanotechnologies.•Statistical optimization methodology was elaborated.
ISSN:1773-2247
DOI:10.1016/j.jddst.2023.104348