Preparation of oxypeucedanin-loaded PLGA-chitosan nanoparticles: Cytotoxicity, apoptosis induction, and anti-angiogenic effects
There are some serious side effects associated with cancer chemotherapy. The medical properties of oxypeucedanin, among a wide range of natural products, are being tested for minimizing off-target effects. The aim of this study was to prepare and characterize oxypeucedanin (OPD)-loaded poly(lactic-c...
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Veröffentlicht in: | Journal of drug delivery science and technology 2023-04, Vol.82, p.104303, Article 104303 |
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Sprache: | eng |
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Zusammenfassung: | There are some serious side effects associated with cancer chemotherapy. The medical properties of oxypeucedanin, among a wide range of natural products, are being tested for minimizing off-target effects. The aim of this study was to prepare and characterize oxypeucedanin (OPD)-loaded poly(lactic-co-glycolic acid (PLGA) nanoparticles (NPs) surface-modified with chitosan (CS) (OPD-PLGA–CS–NP). The cytotoxic, apoptotic, and anti-angiogenesis properties of OPC-NP were then investigated in vitro. OPD-PLGA–CS–NPs showed cytotoxic effects against diverse cancer cell lines, while these effects were less pronounced in HFF normal cells. OPD-PLGA–CS–NPs were also shown to possess apoptotic properties as shown by flowcytometry, fulrecent microscopy and real-time PCR. The antioxidant effects of OPD-PLGA–CS–NPs also demonstrated through scavenging of DPPH and ABTS free radicals. Additionally, OPD-PLGA–CS–NPs were shown to have antiangiogenic properties by using CAM assays. It would be worthwhile to conduct further in vivo studies on animal-bearing tumor models to further demonstrate the properties and anticancer properties of the OPD-PLGA–CS–NPs.
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ISSN: | 1773-2247 |
DOI: | 10.1016/j.jddst.2023.104303 |