p-Coumaric acid in poly(amidoamine) G4 dendrimer: Characterization and toxicity evaluation on zebrafish model

p-Coumaric acid in poly(amidoamine) G4 dendrimer: Characterization and toxicity evaluation on zebrafish model

[Display omitted] •Phase solubility studies using G4PAMAM and p-coumaric acid were conducted.•p-coumaric acid binds to G4 PAMAM dendrimer through electrostatic interactions.•This leads to an increase in p-CA solubility and ensures its controlled-diffusion.•The DPPH scavenging activity of p-CA is mai...

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Veröffentlicht in:Journal of drug delivery science and technology 2023-01, Vol.79, p.104039, Article 104039
Hauptverfasser: Nasr, Gihane, Daakour, Sanaa, Banaszak Holl, Mark M., Attallah, Carla, Hamade, Aline, Greige-Gerges, Helene
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Sprache:eng
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Zusammenfassung:[Display omitted] •Phase solubility studies using G4PAMAM and p-coumaric acid were conducted.•p-coumaric acid binds to G4 PAMAM dendrimer through electrostatic interactions.•This leads to an increase in p-CA solubility and ensures its controlled-diffusion.•The DPPH scavenging activity of p-CA is maintained in the complex form.•The complex was able to abolish G4 PAMAM toxicity on zebrafish model.
ISSN:1773-2247
DOI:10.1016/j.jddst.2022.104039