CRISPR-Cas9 based non-viral approaches in nanoparticle elicited therapeutic delivery

CRISPR-Cas9 genome editing technology has received a considerable attention from the past few years in basic research and has been considered as one of the powerful tools in improvising therapeutic strategies for various genetic disorders. However, with the robust development of non-viral drug delivery systems, nanocarriers have gained a lot of importance in CRIPSPR-Cas9 delivery. The nanocarrier based genome editing may be considered as the most advanced technology in ensuring improvised efficacy. In this review, we have made an attempt to outline the recent developments in the field of CRISPR-Cas9 using non-viral vectors that are used as potential carriers in genome editing platform. This review also emphasizes on the advantages and limitations of non-viral based CRISPR-Cas9 editing platform and as to how one can overcome these limitations. [Display omitted]