Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery

Most cancer disease can be treated by the parenteral anticancer delivery method. The intravenous route takes the wholly bioavailable, accurate dose of the drug immediately to the body, but high plasma concentration has some side effects. Furthermore, i.v. chemotherapy is painful and may cause bleeding and venous thrombosis and discomfort for the patient. Oral chemotherapy is the most accepted alternative way, but some anticancer drugs have low oral bioavailability. Nowadays, nanoparticles have received much attention, and solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have achieved an important place in oral cancer drug delivery. Many researchers studied these nanoparticles as anticancer drug carriers. In this review, we discussed the effects of SLN and NLC encapsulating on stability, cellular toxicity, tumor inhibitory effects, oral bioavailability, and biodistribution of synthetic and herbal anticancer medicines. [Display omitted]