Fabrication of stimuli gated nanoformulation for site-specific delivery of thymoquinone for colon cancer treatment – Insight into thymoquinone’s improved physicochemical properties

Fabrication of stimuli gated nanoformulation for site-specific delivery of thymoquinone for colon cancer treatment – Insight into thymoquinone’s improved physicochemical properties

[Display omitted] •The poor physicochemical properties of thymoquinone were overwhelmed by three different mechanism oriented site specific drug delivery.•Chitosan based formulation because of formation of oxime bond and sialic acid binding showed high cytotoxicity in colon cancer.•Covalent binding...

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Veröffentlicht in:Journal of drug delivery science and technology 2020-02, Vol.55, p.101334, Article 101334
Hauptverfasser: Pushpa Sweety, Joseph, Sowparani, Surendran, Mahalakshmi, Padmanaban, Selvasudha, Nandakumar, Yamini, Dhayandamoorthy, Geetha, Karuppasamy, Ruckmani, Kandasamy
Format: Artikel
Sprache:eng
Schlagworte:
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Science & Technology
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Zusammenfassung:[Display omitted] •The poor physicochemical properties of thymoquinone were overwhelmed by three different mechanism oriented site specific drug delivery.•Chitosan based formulation because of formation of oxime bond and sialic acid binding showed high cytotoxicity in colon cancer.•Covalent binding of thymoquinone with plasma protein, reduced by all three formulations.
ISSN:1773-2247
2588-8943
DOI:10.1016/j.jddst.2019.101334