Stabilization of silver nanoparticles within capsaicin encapsulated metalorganic framework material derived from γ-cyclodextrin

•Capsaicin encapsulated γ-cyclodextrin MOF accomplished from crystal growth.•The synthesis demonstrating 5 nm silver nanoparticles in capsaicin encapsulated γ-cyclodextrin MOF.•First example of stabilization of silver nanoparticle with in drug (capsaicin) encapsulated MOF derived from GRAS status γ-cyclodextrin. Capsaicin, a pungent molecule from red chilli is known for its therapeutic benefits. We envisaged, encapsulation of capsaicin in biocompatible MOF materials derived from γ-cyclodextrin (γ-CD) to overcome solubility and pungency attributes. We accomplished Caps@γ-CDMOF, a capsaicin entrapped CDMOF via in situ addition of capsaicin to the synthesis solution of γ-CD CD MOF and subsequently thoroughly characterized employing PXRD, IR, SEM and NMR techniques. We further accomplished deposition of silver nanoparticles (AgNp) inside the MOF crystals of Caps@γ-CDMOF, which was facilitated by its crystallinity. The AgNp deposition was performed via procedure of reaction–diffusion. This is a first example of CDMOF crystals having an encapsulated drug molecule along with silver nanoparticles distributed across the core of the crystal.