Flash vacuum pyrolysis of aspirin, paracetamol, and their derivatives and analogues

Synthesis and flash vacuum pyrolysis (FVP) of acetylenic esters and ethers of paracetamol and aspirin and their analogues were performed. The products were analyzed, identified, and characterized. Acetylenic esters and ethers of paracetamol resulted in benzofuran, and cyclohepta[b]pyrrol-2(1H)-one. Aspirin and its derivatives produced chromenones, xanthones, indenones, chromenes, and other heterocyclic compounds. [Display omitted] •Synthesis and FVP of aspirinderivatives.•Synthesis and FVP of paracetamol derivatives and analogues.•Valuable routes for synthesis of xanthones and chromenones by FVP.