Synthesis and analysis of antioxidant properties of gallate based bio-MOF for drug delivery application

[Display omitted] •We aim to synthesize CuGA bio-MOF.•Evaluate its antioxidant properties by DPPH assay.•Investigate their potential as a drug delivery vehicle. A porous copper gallate bioinspired metal–organic framework (CuGA bio-MOF) has been synthesized using Copper (ll) chloride dihydrate and gallic acid (a polyphenol) under specific experimental environments to evaluate its antioxidant, drug tagging and release features. Initially, synthesized CuGA Bio-MOF has been analysed through various spectroscopic and microscopic techniques. To proceed further in research and gain a better understanding of readers, we have divided research work into two primary objectives: (a) evaluating the antioxidant properties of CuGA bio-MOF using the 2,2-diphenylpicrylhydrazyl (DPPH) assay and (b) exploring the release of the model drug Ibuprofen (IBU) from CuGA bio-MOF in phosphate-buffered saline (PBS). On confirmation of eminent antioxidant property (79.4 %) of pristine CuGA Bio-MOF, the tagging of Ibuprofen (IBU) on Bio-MOF, i.e., IBU@ CuGA Bio-MOF, has been confirmed through intermolecular hydrogen bonding. Our prolonged release of IBU studies endorsed 90 % release of the drug in 150 min at 37 °C, pH 7.4 in phosphate buffer saline (PBS) from IBU@ CuGA bio-MOF. Overall, the antioxidant features of CuGA bio-MOF and the drug release profile of IBU@CuGA bio-MOF exhibited potential real-world application as a suitable drug carrier.