Coumarin modified Silatrane: A potent probe for Hg(II) ion Detection, biological evaluation and Acetylcholinesterase inhibition

The present work highlights the synthesis of a coumarin-derivatized silatrane (CS) probe for the selective and sensitive detection of Hg(II) ion, DFT investigation, its real sample analysis, biological evaluation, and investigation to test its inhibitory activity against Alzheimer by molecular docking study. [Display omitted] •Coumarin-derivatized silatrane (CS) was successfully synthesized.•CS provides the precise detection of Hg(II) ions, even at low concentrations.•Real sample analysis was also performed to show the practical application of the CS.•CS showed effective antioxidant activity.•CS was docked against Acetylcholinesterase protein to prove its utility as Alzheimer’s disease medication. Mercury contamination poses significant threats to human health, aquatic ecosystems and various living organisms. Effective detection methods are essential for monitoring such contamination. In this investigation, coumarin-derivatized silatrane (CS) was synthesized and meticulously characterized using 1H NMR, 13C NMR and mass spectrometry. The CS compound exhibited outstanding performance in detecting Hg(II), showing excellent selectivity and sensitivity even in the presence of other metal ions with very low limit of detection value (LOD). Furthermore, the CS system exhibited promising performance in analyzing real water samples, yielding a recovery rate exceeding 95 %. Beyond its detection prowess, CS displayed notable biological properties, including significant radical scavenging activity. Molecular docking studies revealed its potential as an inhibitor of acetylcholinesterase (AChE) protein, suggesting a prospective role in combating Alzheimer disease’s disease.