High-sensitivity electrochemical sensing platform for acetaminophen based on MnS/Co3S4 hybrids doped electrochemically reduced graphene oxide nanocomposite

Scheme of MnS/Co3S4-ERGO preparation and detection of acetaminophen (AC). This protocol describes the preparation of manganese nanotubular MnS/Co3S4 by a hydrothermal method and their combination with electrochemically reduced graphene oxide (ERGO) to obtain MnS/Co3S4-ERGO nanocomposites. The composite suspension was then modified onto a glassy carbon electrode (GCE) and the resulting MnS/Co3S4-ERGO was successfully used for the ultrasensitive detection of AC. [Display omitted] •Hollow tubular MnS/Co3S4 hybrids electrode material was prepared via hydrothermal method.•MnS/Co3S4-ERGO were used to construct electrochemcal sensor for acetaminophen (AC) detection.•The linear range (0.01–20 μM and 20–80 μM) and LOD (6.0 nM) for AC detection were achieved.•The sensor was used for the ultrasensitive determination of AC in commercial tablets and human serum samples. In this work, hollow tubular manganese-cobalt sulfide (MnS/Co3S4) hybrids were synthesized using a hydrothermal method and anchored on graphene oxide (GO) by simple ultrasonic dispersion. The nanocomposites were modified onto glassy carbon electrode (GCE) surface by a drop-coating method. After potentiostatic reduction, GO was converted into electrochemically reduced graphene oxide (ERGO), and a sensitive sensor, denoted as MnS/Co3S4-electrochemically reduced graphene oxide modified glassy carbon electrode (MnS/Co3S4-ERGO/GCE), was constructed for acetaminophen (AC) detection. The electrochemical sensing performance of MnS/Co3S4-ERGO/GCE was evaluated in detail. The experimental results show that MnS/Co3S4-ERGO/GCE has excellent electrocatalytic activity for the oxidation of AC. The kinetic process for the electrooxidation of AC on the MnS/Co3S4-ERGO/GCE was studied and the measurement parameters optimized. Under optimal conditions, the oxidation peak current is linear with the concentration of AC in the range of 0.01–20 μM and 20–80 μM, with a detection limit of 6.0 nM. Based on the high sensitivity and excellent selectivity of MnS/Co3S4-ERGO/GCE, the method has been applied for the determination of AC in commercial tablets and human serum samples, with satisfactory recoveries of 98.8%–101.5% and 98.6%–102.8%, indicating high accuracy of the proposed method.