Pharmacological aspects of schiff base metal complexes: A critical review

[Display omitted] •Schiff base ligands and their metal complexes.•Pharmacological application of Schiff base metal complexes.•Anti-bacterial activity.•Anti-fungal activity.•Anti-oxidant activity.•Anti-cancer activity.•Anti-diabetic activity. Multidrug-resistant infections have placed a financial and health burden on the health-care system and population. As a result, human health was faced major issues due to multidrug resistance. In the past few years various organic compounds normally used not for a long time which have a pure organic mechanism of action and instead require more bio-activation or further stimulation.Numerous studies demonstrated that bioactive compounds require trace amounts of metal ions incorporated into their chemistry for improvement of their potential to fight resistance aggressively.Deficiency of metal ions may also cause many diseases such as retardation in growth, severe anemia and cardio-vascular disease in children. These problems are overcomes by introducing new approaches with remarkable pharmacological applications and new action of mechanism that improved the efficiency of the drugs. This review explains the pharmacological importance of Schiff base metal complexes with known chemical structures reported in last five years. Bioinorganic molecules have played an important role for the synthesis of new “Metal Based Drugs”. In recent years, there has been a surge in attention to used Schiff base metal complexes to cure a variety of disorders which are challenging to treat with traditional methods. Metal complexes provided innovative opportunities due to its particular properties and acting as an intermediate between conventional inorganic and organic compounds. In recent years, the great deals of interest in the applications of Schiff base metal complexes for the treatment of several diseases that are challenging to treat with previously used conventional methods.