A novel biosensor based on AAO nanochannels modified with ZnS nanostructure for sensitive detection of tetracycline

[Display omitted] •A confined self-assembly system based on AAO/ZnS for the detection of tetracycline is fabricated.•The current change ratios of tetracycline detection in the presence of different concentration are calculated.•The system is valid for the detection of tetracycline with an excellent sensitivity. Herein, a confined self-assembly system based on AAO/ZnS for the detection of tetracycline is fabricated in this article. According to the optimized experimental results, when the aperture of AAO, the reaction time, and the reaction voltage are 80–100 nm, 30 min, and 1.5 V, respectively, the best assembly system is obtained. In addition, the detection sensitivity of the system for tetracycline is investigated and the experimental results show that this system is effective and sensitive for the detection of tetracycline. This work not only proposes a new idea for combining nanomaterials and biomimetic nanochannels, but also exhibits great potential in improving the sensitivity of detecting biomolecules.