Electrochemical determination of paracetamol at Cu doped ZnO/Nanoparticle with TX-100-surfactant MCPE: A cyclic voltammetric technique

[Display omitted] •ZnO and Cu doped ZnO nanoparticles were prepared using the co-precipitation method.•The electrochemical behavior PA at Cu doped ZnO immobilization with TX-100 surfactant.•The MCPE exhibits excellent selectivity and sensitivity for PA.•Modified electrode was used to analysis of PA in pharmaceutical preparation. Zinc oxide nanoparticles (ZnO/NPs) and Copper doped ZnO nanoparticles (Cu-ZnO/NPs) were prepared using the co-precipitation method and their characterizations were done with X-ray diffraction (XRD), Scanning electron microscope (SEM) and Energy dispersive spectroscopy (EDS) techniques. The prepared Cu-ZnO/NPs were used for the modification of the carbon paste electrode (CPE), the Cetyl Trimethyl Ammonium Bromide (CTAB) and Triton-X 100 (TX-100) surfactants were immobilization on the surface of Cu-ZnO/MCPE, the TX-100 modified electrode improved the more redox property with increasing the peak current for Paracetamol (PA) compare to Cu-ZnO/CTAB/MCPE. From the pH study confirms that the equal number of electrons and protons transfer mechanism involved at the MCPE. The cyclic voltammetry (CV) technique demonstrated the oxidation of both PA and Adrenaline (AD) was found to be adsorption controlled. The electrochemical response of PA and AD was linear in the µM concentration range and the limit of detection and limit of quantification was found to be 4.6 µM and 16.2 µM for PA and 3.9 µM and 13.2 µM for AD respectively, the effect of interference study was examined by using the differential pulse voltammetric technique (DPV), the Cu-ZnO/TX-100/MCPE shows an excellent selectivity towards PA in presence of different AD concentration. In present study commercial PA tablet also studied.